用 Carlens 管隔开两组狗(每组7条)的左、右支气管,向右侧肺灌入自来水25ml/kg(体重),以模拟溺水。Ⅰ组动物灌水15分钟后处死,发现右侧肺底出现轻微淤血;光镜下可见肺泡、肺泡管扩张,肺泡壁断裂;电镜下见血气屏障损伤,表现为Ⅰ型上皮细胞突出,基底膜肿胀,内皮细胞的囊泡形成。Ⅱ组动物灌水3小时左右,右侧肺出现 The left and right bronchi of two groups of dogs (7 in each group) were separated by a Carlens tube and the right lungs were infused with tap water 25 ml / kg (body weight) to simulate drowning. Group I animals were sacrificed 15 minutes after irrigation and found that there was slight congestion in the right lung bottom. Alveolar and alveolar tube dilated and alveolar wall were disrupted under light microscope. Blood gas barrier injury was observed under electron microscope, showing type I epithelial cell protrusion and basement membrane swelling , Vesicle formation of endothelial cells. Group Ⅱ animals, irrigation for about 3 hours, the right lung appears