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为研究血浆IL 1 β和IL 6水平与脑不对称程度的关系 ,利用伸爪取食法 ,记录反映小鼠脑不对称程度的右利分(RPE ) ,生理盐水或细菌脂多糖 (lipopolysaccharide ,LPS )刺激 4h后ELISA法检测其血浆中IL 1 β和IL 6水平。结果表明 :血浆IL 1 β水平在正常生理状况下随RPE的升高而呈抛物线样分布 ,LPS刺激 4h后血浆IL 1 β水平随RPE的升高而下降 ,呈直线负相关分布 ;IL 6水平在正常生理状况下随RPE的升高而升高 ,呈直线正相关分布 ,LPS刺激 4h后则呈直线负相关分布。由于IL 1 β和IL 6主要由单核 /巨噬细胞分泌 ,这一结果提示脑不对称小鼠单核 /巨噬细胞功能存在差异 ,脑不对称对免疫功能的影响程度与右利分有关
In order to study the relationship between plasma levels of IL-1β and IL-6 and the degree of brain asymmetry, right elbow (RPE), saline or bacterial lipopolysaccharide LPS) for 4 hours, the levels of IL-1β and IL-6 in plasma were detected by ELISA. The results showed that the level of plasma IL-1βwas parabolic with the increase of RPE under normal physiological conditions. The level of IL-1β decreased with the increase of RPE after LPS stimulation for 4h, Under normal physiological conditions with the rise of RPE increased, showed a positive linear correlation distribution, LPS 4h after a linear negative correlation. Since IL-1β and IL-6 are mainly secreted by monocytes / macrophages, this result suggests that there is a difference in the function of monocytes / macrophages in brain-asymmetric mice. The extent of brain asymmetry in immune function is related to right-sidedness