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有机化合物还原时,还原则的选择是一个重要用题。还原剂无论在植物成分化学中天然产物构造式的确定,或有机合成药物中的合成反应,都占重要地位。选择时必须考虑:(1)还原剂对反应物质或产物无损害,(2)还原进行,顺利,(3)操作简易,(4)还原剂容易制备用备,(5)还原时副产物生成少,(6)还原收获率高。钠硼氢能符合以上数个要求,且有还原选择性高的优点,因此在最近几年来应用得很多。本文内容包括钠硼氢的各种制法、性状、含量测定、对有机化合物各种功能团的作用、实验条件的选择,及与其他类似还原则的比较,最后以其对碳水化合物及甾体的作用为例,简单介绍该还原则应用的一般情况。
When organic compounds are reduced, the choice of reduction is an important issue. The reductant plays an important role both in the determination of the natural product structure in the plant component chemistry and in the synthesis of organic synthetic drugs. The selection must take into account: (1) the reductant is not detrimental to the reaction mass or product, (2) the reduction is carried out smoothly, (3) the operation is simple, (4) the preparation of the reducing agent is easy to prepare, (5) the by- Less, (6) high recovery rate. Sodium borohydride can meet the above requirements, and has the advantages of high reduction selectivity, it has been applied in recent years a lot. This article includes various methods of sodium borohydride, traits, determination, the role of various functional groups of organic compounds, the choice of experimental conditions, and compared with other similar reduction, and finally its carbohydrates and steroids For example, a brief introduction to the restoration of the general application of the situation.