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本文用酶联免疫吸附夹心法检测94例胃良、恶性疾患的胃液及27例唾液CEA含量。其中,22例胃癌胃液CEA含量(152.2±85.6ng/ml)明显高于26例浅表性胃炎(26.4±34.6ng/ml)、17例萎缩性胃炎(33.5±35.0ng/ml)、16例肠上皮化生(38.9±49.1ng/ml)及13例异型增生(68.8±46.6ng/ml),异型增生组又明显高于浅表性胃炎和萎缩性胃炎组。27例唾液CEA(18.7±23.2ng/ml)与胃液CEA无相关性。免疫组化结果表明组织CEA染色与胃液CEA含量无恒定关系。并讨论了胃液和唾液内CEA测定的临床意义。
This article used enzyme-linked immunosorbent assay to detect CEA content in 94 cases of gastric benign and malignant diseases and 27 cases of saliva CEA. Among them, 22 cases of gastric cancer gastric fluid CEA content (152.2 ± 85.6ng/ml) was significantly higher than 26 cases of superficial gastritis (26.4 ± 34.6ng/ml), 17 cases of atrophic gastritis (33.5 ± 35.0ng/ml), 16 cases Intestinal metaplasia (38.9±49.1ng/ml) and 13 dysplasia (68.8±46.6ng/ml) were significantly higher in the dysplasia group than in the superficial gastritis and atrophic gastritis groups. There was no correlation between CEA (18.7±23.2ng/ml) and gastric juice in 27 cases. Immunohistochemistry results showed that there was no consistent relationship between tissue CEA staining and CEA content in gastric juice. The clinical significance of CEA in gastric juice and saliva was discussed.