肾上腺糖皮质激素(简称激素)已被广泛应用于治疗多种疾病。长期应用外源性激素可抑制下丘脑-垂体-肾上腺皮质(HPA)轴达数月之久,而短期大剂量激素是否可致HPA功能受抑仍有争议。临床上短期大剂量激素治疗新生儿疾病时,对新生儿HPA轴和肾上腺皮质功能,以及组织形态和超微结构的影响,国内至今尚未见有这方面的报道。国外的研究由于实验方法、观察指标和种族不同等因素,其结果也不尽一致。 Adrenal glucocorticoids (Hormone) has been widely used to treat many diseases. Long-term use of exogenous hormones can inhibit the hypothalamic-pituitary-adrenal cortex (HPA) axis for several months, and short-term high-dose hormone can cause HPA dysfunction is still controversial. Clinical short-term high-dose hormone treatment of neonatal disease, neonatal HPA axis and adrenocortical function, as well as the impact of tissue morphology and ultrastructure, so far no such reports in China. Foreign research due to experimental methods, observation indicators and ethnic differences and other factors, the results are not the same.