已知饮食中过量的多不饱和脂肪酸对7,12-二甲基苯蒽(DMBA)诱导的鼠乳腺肿瘤生成有促进作用,其确切机制未明.多不饱和脂肪酸是合成前列腺素的前体物质.已证实前列腺素E(PGE)对自然杀伤细胞(NK)、巨噬细胞、B和T细胞有抑制作用,可能是使瘤宿主呈免疫抑制状态的重要因素.NK细胞在宿主抗肿瘤中超重要作用,但至今无明确证据说明NK细胞 Excessive polyunsaturated fatty acids in the diet are known to promote the formation of murine breast tumors induced by 7,12-dimethylbenzyl anthracene (DMBA), the exact mechanism of which is unknown. Polyunsaturated fatty acids are precursors to the synthesis of prostaglandins PGE has been shown to inhibit natural killer (NK), macrophage, B and T cells and may be an important factor in the immunosuppressive state of tumor hosts.NK cells are overexpressed in host antitumor However, so far no clear evidence of NK cells