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常用纤维蛋白原的吸附特性来比较和研究材料的血液相容性。将自行合成的正电磷脂ＤＰＰＥＬ膜铺展在金膜表面，测量了膜表面的接触角及对纤维蛋白原的动态吸附特性，并与裸金膜、中性磷脂ＤＳＰＣ膜进行了比较。结果表明：ＤＳＰＣ膜、ＤＰＰＥＬ膜和裸金膜的接触角分别为３８°０５′，５７°２０′和７８°２４′。在相同的纤维蛋白原溶液浓度条件下，裸金膜表面吸附纤维蛋白原的速率最快，饱和吸附量最大（３．５０ｎｇ／ｍｍ２）；磷脂ＤＳＰＣ膜表面吸附纤维蛋白原的速度最低，饱和吸附量也最小（１．００ｎｇ／ｍｍ２）；磷脂ＤＰＰＥＬ膜吸附速率也较快，饱和吸附量为１．７５ｎｇ／ｍｍ２。表明纤维蛋白原在界面上的吸附特性与材料表面疏水性质和带电特性相关。ＰＣ头良好的亲水性和电中性，是其能改善生物医用材料血液相容性的重要原因。
Common fibrinogen adsorption characteristics to compare and study the material’s blood compatibility. The self-synthesized cationic phospholipid DPPEL membrane was spread on the surface of the gold membrane. The contact angle of the membrane surface and the dynamic adsorption of fibrinogen were measured and compared with bare gold membrane and neutral phospholipid DSPC membrane. The results show that the contact angles of DSPC film, DPPEL film and bare gold film are 38 ° 05 ’, 57 ° 20’ and 78 ° 24 ’respectively. Under the same concentration of fibrinogen solution, the rate of adsorption of fibrinogen on the surface of bare gold film was the fastest, with the maximum amount of saturated adsorption (3.50ng / mm2); the adsorption rate of fibrinogen on the surface of phospholipid DSPC membrane was the lowest, saturated adsorption (1.00ng / mm2). Phospholipid DPPEL membrane adsorption rate was also faster, with a saturated adsorption capacity of 1.75ng / mm2. It is indicated that the adsorption characteristics of fibrinogen at the interface are related to the hydrophobic properties and charge characteristics of the surface of the material. The good hydrophilicity and neutrality of PC head is an important reason that it can improve the blood compatibility of biomedical materials.