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心钠素(ANP)和肾素—血管紧张素系统(RAS)在血压调节中起相互制约相互调节的作用。我们过去的工作证明,慢性缺氧可影响这两个环节,使血压维持在正常下限水平。慢性缺氧时自发性高血压大鼠的血压调节是否也存在类似影响,国内外尚未见报道。实验用同龄雄性SHR和WKY大鼠,各分为平原组(N)和缺氧组(H),在缺氧前和缺氧15天后(平原组也在相应时间)于清醒状态下测量尾动脉血压,然后在乌拉坦(1.2g/kg)腹腔麻醉下,行右心导管术测肺动脉平均压(MPAP)。取动脉血用放射免疫法测血浆ANP,肾素活性(RA)和AII。结果表明:SHR—N(n=7)和SHR—H(n=9)的血压均明显高于WKY—N(n=9)。SHR—N和-H组血浆ANP、RA、AII含量均明显高于WKY—N。WKY—
Atrial natriuretic factor (ANP) and renin-angiotensin system (RAS) play a role in the regulation of blood pressure in regulating each other. Our past work proves that chronic hypoxia can affect both aspects and maintain blood pressure at the normal lower limit. Chronic hypoxia in spontaneously hypertensive rats whether there is a similar impact on blood pressure regulation, has not been reported at home and abroad. Experimental male SHR and WKY rats of the same age were divided into two groups: the placental group (N) and the hypoxic group (H). The caudal artery was measured in awake state before anoxia and 15 days after hypoxia Blood pressure was measured with right heart catheterization and mean arterial pressure (MPAP) under abdominal anesthesia with urethane (1.2 g / kg). Blood samples were collected for determination of plasma ANP, renin activity (RA) and AII by radioimmunoassay. The results showed that the blood pressure of SHR-N (n = 7) and SHR-H (n = 9) were significantly higher than that of WKY-N (n = 9). The contents of plasma ANP, RA and AII in SHR-N and -H groups were significantly higher than those in WKY-N. WKY-