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克隆刺激因子(CSFs)的分类是根据骨髓在半固体培养基上受到刺激所形成克隆的不同类型而划分的。4种典型的CSFs为:(1)白细胞介素3(IL-3),刺激红、粒及巨噬细胞克隆形成;(2)GM-CSF,刺激粒和巨噬细胞克隆形成;(3)GM-CSF,刺激粒细胞克隆形成;(4)M-CSF,刺激巨噬细胞克隆形成。白细胞介素、CSF活性表现在体内外直接作用于造血组织并刺激相应类型细胞生长。它们的作用和受体分布有相对特异性。IL-1能协同GM-CSF和M-CSF作用于高纯度干细胞克隆形成。IL-4除了促进T细胞和肥大细胞生长,增加MHCⅡ类抗原表达,促进B细胞产生IgG_1及IgE外,最近又发现它能诱导纤维母细胞产生G和M-CSF,并在人骨髓克隆实验中与G-CSF有协同作用,但它本身无克隆形成活性。IL-5能刺激人骨髓嗜酸性克隆并能使小鼠酸性克隆分化。IL-6除有B细胞分化等活性
The classification of clonally stimulating factors (CSFs) is based on the different types of clones in which bone marrow is stimulated on semi-solid media. Four typical CSFs are: (1) interleukin 3 (IL-3), which stimulates the formation of red, granulocyte and macrophage colony formation; (2) GM-CSF, stimulating granule and macrophage colony formation; GM-CSF, stimulating granulocyte colony formation; (4) M-CSF, stimulating macrophage colony formation. Interleukin, CSF activity is shown to act directly on hematopoietic tissues in vitro and in vivo and stimulate the growth of the corresponding type of cells. Their role and receptor distribution are relatively specific. IL-1 acts in synergy with GM-CSF and M-CSF on high-purity stem cell cloning. In addition to promoting the growth of T cells and mast cells, increasing the expression of MHC class II antigens, and promoting the production of IgG1 and IgE by B cells, IL-4 has recently been found to induce G and M-CSF production in fibroblasts and in human bone marrow cloning experiments Synergistic effect with G-CSF, but no clonal formation activity per se. IL-5 stimulates human bone marrow eosinophilic clones and allows mouse acidic clones to differentiate. IL-6 in addition to B cell differentiation and other activities