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目的:探讨归脾丸抗乙醇致小鼠胃溃疡的机制,为临床使用中药治疗乙醇致胃溃疡提供理论依据。方法:该实验通过检查胃溃疡指数,检测血清和胃组织中NO含量,测定血浆及胃黏膜中GSH-PX的含量,来观察归脾丸对乙醇致小鼠胃溃疡的影响。结果:归脾丸能明显降低溃疡指数(P<0.01),提高血清和胃组织中NO含量(P<0.01),归脾丸能明显提高乙醇致小鼠胃溃疡模型中血浆和胃黏膜中GSH-PX的含量(P<0.05)。结论:归脾丸可对抗乙醇致胃溃疡。
Objective: To explore the mechanism of Guipi Wan on gastric ulcer induced by ethanol in mice and provide a theoretical basis for the clinical use of traditional Chinese medicine to treat gastric ulcer caused by ethanol. Methods: In this experiment, the gastric ulcer index was measured, the content of NO in serum and gastric tissue was detected, and the content of GSH-PX in plasma and gastric mucosa was measured to observe the effect of Guipi Wan on gastric ulcer induced by ethanol. Results: Guipi Pill can significantly reduce the ulcer index (P <0.01), increase the content of NO in serum and gastric tissue (P <0.01), and Guipi Pill can significantly improve the gastric mucosal GSH in ethanol - induced gastric ulcer model -PX content (P <0.05). Conclusion: Guipi Pills can antagonize ethanol-induced gastric ulcer.