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目的了解浙江省湖州地区女性人乳头瘤病毒(human papilloma virus,HPV)亚型分布状况及年龄相关性,为本地区女性宫颈癌的防治及HPV疫苗的研制提供科学参考。方法收集2011年1月至2013年12月于湖州市中心医院就诊的10 680份女性宫颈脱落细胞标本,以基因芯片方法进行HPV-DNA亚型检测及统计学分析。结果10 680份标本,检出HPV阳性标本2865例,感染率为26.83%(2865/10 680)。亚型分布构成比排在前3位的分别为HPV16为17.52%(718/4099),HPV52为15.32%(628/4099),HPV58为12.42%(509/4099)。高危感染占82.41%(2361/2865),低危感染占8.90%(255/2865),高低危混合感染8.69%(249/2865);<20岁年龄组3种感染类型感染率均最高。感染亚型以单一亚型感染为主(69.56%),单一亚型感染率最高的是45~49岁年龄组为77.56%,多重亚型感染率最高的是<20岁年龄组为60.38%。结论湖州地区门诊女性HPV感染率为26.83%,亚型以HPV16,18,52为主。20岁以下高感染率、高多重感染率说明HPV感染有低龄化多亚型化倾向,值得引起高度重视。
Objective To investigate the distribution and age-related distribution of female human papilloma virus (HPV) in Huzhou area of Zhejiang province and to provide scientific references for the prevention and treatment of HPV in women in this area. Methods A total of 10 680 female cervical exfoliated cells from January 2011 to December 2013 in Huzhou Central Hospital were collected for detection of HPV-DNA subtypes and statistical analysis by gene chip method. Results A total of 10 680 samples were collected, of which 2865 were positive for HPV. The infection rate was 26.83% (2865/10 680). The distribution of subtypes was 17.52% (718/4099) for HPV16, 15.32% (628/4099) for HPV52 and 12.42% (509/4099) for HPV58, respectively. High-risk infection accounted for 82.41% (2361/2865), low-risk infection accounted for 8.90% (255/2865), mixed infection of high and low risk of 8.69% (249/2865); <20 years of age group the highest infection rates of the three types of infection. The infection subtypes were mainly single subtypes (69.56%). The single subtype infection rate was 77.56% in 45-49 years old group and 60.38% in <20 years old group. Conclusion The prevalence of HPV infection in outpatients in Huzhou area is 26.83%. The subtype is HPV16,18,52. High infection rates under 20 years old, high multiple infection rate shows that HPV infection has the tendency of younger subtypes, which deserves great attention.