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我们通过对39例骨软化症(Osteomalacia,OM),69例再生不良性骨病(aplastic bonedisease,ABD)的尿毒症患者骨活检资料分析,证明这两种类型的共同组织学特征为破骨细胞数减少,骨矿化率(BMR)和骨生成率(BFR)降低,矿化时间(MLT)延长,故属低运转性(low turnover)。两组比较,OM组的骨前质面积、长度和宽度均显著增加(P<0.01),MLT更为延长(P<0.05),而ABD组骨小梁面积显著减少(P<0.05)。OM和ABD组的骨铝阳性率分别为84.6%和64.2%,骨铝沉积量分别为65.8±42%和46.9±44%(p<0.05)。两组的骨铝沉积量与BFR之间呈负相关(r=-0.4635,-0.3886;P<0.01)。本文讨论了这两种低运转性尿毒症骨病与铝中毒的关系,发病机理及防治措施。
We analyzed bone biopsy data of 39 uremic patients with osteomalacia (OM) and 69 with aplastic bonedisease (ABD) and found that the two types of common histological features were osteoclast The number of BMR and BFR decreased and the mineralization time (MLT) was prolonged. Therefore, it is a low turnover. Compared with the two groups, the area, length and width of the bone in OM group were significantly increased (P <0.01), MLT was longer (P <0.05), while the trabecular area of ABD group was significantly reduced (P <0.05). The positive rates of osteal aluminum in OM and ABD groups were 84.6% and 64.2% respectively, and the deposition rates of bone aluminum were 65.8 ± 42% and 46.9 ± 44%, respectively (p <0.05). There was a negative correlation between BFR and deposition of bone aluminum in both groups (r = -0.4635, -0.3886; P <0.01). This article discusses the relationship between these two low-functioning uremic bone disease and aluminum poisoning, pathogenesis and prevention measures.