2. 您的位置
3. 首页
4. 期刊论文
5. p38 MAPK信号通路对肝纤维化发生发展的影响

p38 MAPK信号通路对肝纤维化发生发展的影响

来源 :养生大世界 | 被引量 : 0次 | 上传用户：xhbing520

【摘 要】

：

据统计,25％-40％肝纤维化会引发肝硬化,最终可发展为肝癌,严重威胁人类的生命健康.现已知肝纤维化是一个可逆转的病变,深入研究肝纤维化发生发展的机制,势必有利于各种急、慢性肝病的预防和治疗.迄今,临床上尚缺乏有效逆转或阻止其发生发展的药物,故本综述重点围绕肝纤维化所涉及p38 MAPK信号通路,来进一步阐明肝纤维化与p38 MAPK信号通路的关系,以期为更好地认识肝纤维化和临床治疗肝纤维化提供新思路.

【作 者】

：

赵婧瑶 秦燕 

【机 构】

：

大理大学基础医学院,云南大理 671000

【出 处】

：

养生大世界

【发表日期】

：

2021年11期

【关键词】

：

肝纤维化 p38 MAPK信号通路 肝星状细胞 

下载到本地 , 更方便阅读

下载此文 赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

据统计,25％-40％肝纤维化会引发肝硬化,最终可发展为肝癌,严重威胁人类的生命健康.现已知肝纤维化是一个可逆转的病变,深入研究肝纤维化发生发展的机制,势必有利于各种急、慢性肝病的预防和治疗.迄今,临床上尚缺乏有效逆转或阻止其发生发展的药物,故本综述重点围绕肝纤维化所涉及p38 MAPK信号通路,来进一步阐明肝纤维化与p38 MAPK信号通路的关系,以期为更好地认识肝纤维化和临床治疗肝纤维化提供新思路.

其他文献

Lanthanide-Hypophosphite Frameworks with Guanidinium Guest Showing High Proton Conductivity

Proton-conductive metal-organic frameworks (MOFs) have attracted great attention for their promising application in membrane fuel cells.To explore proton-conductive MOFs with high performance,here we present four lanthanide-hypophosphite frameworks with d

期刊

LanthanidesHypophosphiteMetal-organic frameworksProton transportMagnetic pro

Anisotanols A—D,Four Norsesquiterpenoids with an Unprece-dented Sesquiterpenoid Skeleton from Anisod

Anisotanols A—D (1-4),four new compounds possessing an unprecedented sesquiterpenoid skeleton with a congested tricyclic 6/3/5 ring system,were obtained from Anisodus tanguticus.Their structures were elucidated by comprehensive spectroscopic tech-niques,a

期刊

Anisodus tanguticusTerpenoidsStructure elucidationAnisotane-typeAngiogenesis

Palladium-Catalyzed Sequential Cyclization/Functionalization of Oxime Ethers with Unactivated Vinyl

A novel and viable palladium-catalyzed sequential cyclization/functionalization of alkynone O-methyloximes with unactivated vinyl ethers under aerobic conditions was described.The structure of the products could be successfully controlled by varying the n

期刊

PalladiumAlkenesAlkynesAnnulationCross-coupling

A pH Self-Monitoring Heterogeneous Multicompartmental Proteinosome with Spatiotemporal Regulation of

Inspired by the intricate eukaryotic cell structure,the spontaneously assembling multicompartments capable of spatiotemporally regulated biomacromolecules transportation is still a challenge.Here,a heterogeneous proteinosome-based multicompartment was des

期刊

MulticompartmentVesiclesSensorsSpatiotemporal regulationDrug delivery

Electrosynthesis of Azobenzenes Directly from Nitrobenzenes

The electrochemical reduction strategy of nitrobenzenes is developed.The chemistry occurs under ambient conditions.The protocol uses inert electrodes and the solvent,DMSO,plays a dual role as a reducing agent.Its synthetic value has been demonstrated by t

期刊

Azo compoundsNitro reductionElectrochemistryNitrobenzenesGreen chemistry

半潜式平台自由衰减时域运动数值仿真

建立陵水17-2半潜式平台运动学数值仿真模型,并对其不同自由度的自由衰减进行运动仿真.为确保模型的可信度,采用缩尺比模型试验对仿真模型进行校核,将给定初始条件下自由衰减运动响应的仿真结果与模型试验结果进行对比,两者基本吻合.基于自由衰减曲线计算平台阻尼系数,对阻尼力(矩)时历曲线进行数值分析,结果证明可基于该仿真模型开展陵水17-2平台海上作业运动评估.

期刊

半潜式平台自由衰减模型试验运动仿真

考虑多场耦合的碰撞载荷下半潜式风机动力响应

以DeepCwind浮式风机为研究对象,确定典型碰撞事故场景,提出一种风-浪-系泊耦合场景下船舶-浮式风机碰撞动态响应数值分析方法.基于FAST程序获得不同海况下半潜式风机的气动推力、水动力参数和系泊张力,再利用LS-DYNA中的Subroutine Loadud子程序完成加载以实时更新计算水动力载荷,同时考虑系泊载荷和气动载荷的耦合作用.在此基础上,基于LS-DYNA软件开展多场耦合的碰撞载荷作用下浮式风机动力响应研究,分析船舶撞击对浮式风机动力响应的影响.结果 显示:撞击船的动能大部分转化为浮式风机的

期刊

半潜式风机船舶碰撞多场耦合动力响应数值仿真

FPSO典型舱段极限强度

针对浮式生产储卸油装置(Floating Production Storage and Offloading,FPSO)主船体货舱区域结构采用Abaqus准静态分析法,考虑材料非线性因素和船舶工作海域实际海况,建立3档强框模型并对其在垂向弯矩和30°艏斜浪作用下的极限承载能力进行研究.采用整船波浪直接计算得到的弯矩幅值响应算子比值确定联合载荷中垂向与水平载荷加载关系.研究表明:在垂向载荷作用下结构抵抗中拱弯矩的能力更强;引入水平载荷后结构抵抗垂向外载荷能力降低且水平载荷对中垂极强弯矩的影响更大,极限弯矩发

期刊

FPSO极限强度联合载荷准静态分析非线性有限元

Rational Design and Synthesis of Interlocked [2]Catenanes Fea-turing Half-Sandwich Cp*Rh/Ir Units an

The construction of interlocked topologies by metal-cation-template methods has been extensively explored.However,construction of these species using template-free chemical self-assembly methods is hard to rationally achieve due to the inherent unpredicta

期刊

Self-assemblyPi interactionsStacking interactionsHalf-sandwiched Cp*·Rh/IrIn

Circularly Polarized Luminescence and SHG Chiral Signals of Helical TPE Macrocycles

One pair of new enantiomers of helical tetraphenylethylene (TPE) tetracycle tetradodecylurea,which show aggregation-induced emission (AIE) enhancement effect,were synthesized by attaching four dodecyl chains to a helical TPE tetracycle tetramine through u

期刊

Helical TPE macrocyclesAggregationCircularly polarized luminescenceHost-guest