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目的:观察缬沙坦对腹主动脉缩窄(AAC)大鼠血压及心血管重构的影响,探讨其心血管保护作用及其机制。方法:选择AAC术后的24只雄性Sprague Dawley大鼠,随机分成3组:AAC对照(AAC)组、AAC低剂量缬沙坦(AAC-LD)组(1mg.kg-1.d-1)和AAC高剂量缬沙坦(AAC-HD)组(30mg.kg-1.d-1),另选8只大鼠作为假手术(Sham)组。治疗6周后,检测各组大鼠颈动脉收缩压、左室质量指数(LVMI)、心肌胶原容积分数(CVF)、冠状动脉壁厚度/内径比值、主动脉及肠系膜上动脉中膜厚度/内径比值、血浆及心血管组织中血管紧张素Ⅱ(AngⅡ)和醛固酮(Ald)水平。结果:与AAC组比较,AAC-LD组颈动脉压无统计学差异(P>0.05),而LVMI、CVF、冠状动脉壁厚度/内径比值、主动脉及肠系膜上动脉中膜厚度/内径比值明显降低(P<0.05或P<0.01)。AAC-HD组上述指标均明显低于AAC组(P<0.01)。结论:缬沙坦能剂量依赖性降低AAC大鼠血压,改善心血管重构,其对心血管的保护作用部分独立于降压作用之外。
Objective: To observe the effects of valsartan on blood pressure and cardiovascular remodeling in abdominal aorta (AAC) rats and to investigate its cardiovascular protective effect and its mechanism. Methods: Twenty-four male Sprague Dawley rats were randomly divided into three groups: AAC control group (AAC), AAC low-dose AAC-LD group (1mg.kg-1.d-1) And AAC high dose valsartan (AAC-HD) group (30mg.kg-1.d-1), and another 8 rats as sham group. After 6 weeks of treatment, the carotid artery systolic pressure, left ventricular mass index (LVMI), myocardial collagen volume fraction (CVF), coronary artery wall thickness / inner diameter ratio, aortic and superior mesenteric artery medial thickness / Ratio, plasma and cardiovascular levels of angiotensin Ⅱ (Ang Ⅱ) and aldosterone (Ald) levels. Results: Compared with AAC group, carotid arterial pressure in AAC-LD group had no statistical difference (P> 0.05). LVMI, CVF, ratio of coronary artery wall thickness / inner diameter and ratio of medial thickness / diameter in aorta and superior mesenteric artery were significantly Decreased (P <0.05 or P <0.01). The above indexes in AAC-HD group were significantly lower than those in AAC group (P <0.01). Conclusion: Valsartan can decrease blood pressure and improve cardiovascular remodeling in a dose-dependent manner in a dose-dependent manner. The protective effect of valsartan on cardiovascular function is independent of that of antihypertensive effect.