论文部分内容阅读
硝呋烯脘(mitrovin)是一种常用的禽畜促生长剂,但迄今还不了解它对胚胎发育有无不利作用。本研究用小鼠测试了硝呋烯腙的胚胎毒性。经口分别给予4组妊娠d 9-11的小鼠硝呋烯腙5,50,500和5000 mg/kg,另两组小鼠分别给予2.5％吐温80溶液和乙酰水杨酸280 mg/kg,作为空白对照和阳性对照。于d 18剖腹检查。结果:空白对照组和乙酰水杨酸组胚胎吸收率分别为4.17％和9.52％。5,50,500和5000 mg/kg硝呋烯腙组依次为7.38％,8.70％,18.35％和14.73％;其中500和5000mg/kg组胚胎吸收率明显大于空白对照组(P<0.005)。空白对照组和阳性对照组胚胎率分别为1.82 ％和38.46％;5,50,500和5000 mg/kg硝呋烯脓依次为9.52％,
Mitrovin is a common poultry growth promoter, but so far it has not been known whether it has any adverse effect on embryonic development. In this study, mice were tested for embryotoxicity of nifedizin. Four groups of mice given nifedizone 5, 9, 500, and 5000 mg / kg respectively during the pregnancy d 9-11 were given orally. The other two groups were given 2.5% Tween 80 solution and acetylsalicylic acid 280 mg / kg, As blank control and positive control. C 18 laparotomy. Results: The embryo absorption rates of blank control group and acetylsalicylic acid group were 4.17% and 9.52% respectively. The rates of embryo absorption in the groups of 500, 5000 and 5000 mg / kg were 7.38%, 8.70%, 18.35% and 14.73%, respectively, compared with those of the control group (P <0.005). The embryonic rates of blank control group and positive control group were 1.82% and 38.46%, respectively; the rates of 5, 50, 500 and 5000 mg / kg nitrofurantoin were 9.52%