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目的：探讨利培酮与氯氮平对精神分裂症患者糖脂代谢的影响。方法将120例精神分裂症患者按照随机数字表法分为两组，分别口服利培酮、氯氮平治疗，观察6周。于治疗前后检测两组患者血糖、血脂水平的变化。结果治疗后利培酮组仅血糖各项指标较治疗前显著升高(P <0.01)，而氯氮平组血糖、血脂各项指标均较治疗前显著升高，且显著高于利培酮组(P <0.01)。利培酮组治疗后空糖血糖异常增高率为1.7%，氯氮平组为41.7%，利培酮组显著低于氯氮平组(P <0.01)。结论利培酮与氯氮平对精神分裂症患者的糖脂代谢均有不同程度的影响，氯氮平的影响更明显，临床上选用氯氮平治疗时应密切监测各项代谢指标的变化。“,”Objective To explore the influences of risperidone and clozapine on glucolipid metabolism of patients with schizophrenia.Methods A total of 120 schizophrenia patients were assigned to two groups according to random number table and treated with risperidone or clozapine for 6 weeks.Blood sugar and fat changes were detected before and after treatment.Results After treatment all indexes of only blood sugar in risperidone group increased more significantly compared with pretreatment (P < 0.01 ),so did those of both blood sugar and fat in clozapine group and were significantly higher than those in risperidone group (P <0.01).After treatment the heightening rate of fasting plasma glucose abnormality was 1.7%in risperidone group and 41.7% in clozapine group,the former significantly lower than the latter (P <0. 01).increased abnormality,no diabetes standard has been found.,the difference of two groups of blood. Conclusion Both risperidone and clozapine have influences of different degrees,especially clozpaine,chan-ges of all metabolic indexes should be closely observed when patients are treated with clozapine.