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目的：研究Ｃ－ｅｒｂＢ－２和组织蛋白酶Ｄ（Ｃａｔｈ－Ｄ）表达与食管癌分级、浸润、转移和预后的关系，以及 Ｃ－ｅｒｂＢ－２表达与 Ｃａｔｈ－Ｄ表达的相互关系。方法应用微波－ＳＰ免疫组化法，检测 ６５例食管鳞状细胞癌组织中 Ｃ－ｅｒｂＢ－２和 ＰＣＮＡ表达水平。结果在食管病中 Ｃ－ｅｒｂＢ－２和Ｃａｔｈ－Ｄ表达阳性率分别为５０．８％和 ６４．４％。Ｃ－ｅｒｂＢ－２和 Ｃａｔｈ－Ｄ表达均与肿瘤分级、浸润、淋巴结转移和预后相关。Ｃ－ｅｒｂＢ－２表达与Ｃａｔｈ－Ｄ表达呈正相关。结论Ｃ－ｅｒｂＢ－２和Ｃａｔｈ－Ｄ是食管癌高度恶性和预后不良的重要生物学指标。食管癌 Ｃ－ｅｒｂＢ－２和Ｃａｔｈ－Ｄ表达具有可能的相互协同作用。
OBJECTIVE: To investigate the relationship between the expression of C-erbB-2 and cathepsin D (Cath-D) and the grade, infiltration, metastasis and prognosis of esophageal carcinoma and the relationship between C-erbB-2 expression and Cath-D expression. Methods The expression of C-erbB-2 and PCNA in 65 cases of esophageal squamous cell carcinoma were detected by microwave-SP immunohistochemistry. Results The positive rates of C-erbB-2 and Cath-D in esophageal disease were 50.8% and 64.4% respectively. C-erbB-2 and Cath-D expression were related to tumor grade, invasion, lymph node metastasis and prognosis. C-erbB-2 expression was positively correlated with Cath-D expression. Conclusions C-erbB-2 and Cath-D are important biological indicators of esophageal cancer with high malignancy and poor prognosis. Esophageal C-erbB-2 and Cath-D expression have a possible synergistic effect.