妊娠合并糖尿病,包括糖尿病(DM)合并妊娠、妊娠期糖尿病(GDM)。前者指在原有DM基础上合并妊娠。GDM系指妊娠期首次发生或发现的任何程度的糖耐量异常。随着经济的发展、生活方式的改变,近年来GDM的发病率正逐年上升。GDM可导致一系列母婴并发症。妊娠期胰岛素抵抗(IR)增加是GDM公认的主要病理生理机制,但GDM发生的具体机理不详。新近研究发现的多功能脑肠肽—Obestatin和Ghrelin,在肥胖和能量代谢方面发挥着重要作用,而且与 Pregnancy with diabetes, including diabetes mellitus (DM) with pregnancy, gestational diabetes (GDM). The former refers to the merger of pregnancy on the basis of the original DM. GDM refers to any degree of impaired glucose tolerance that occurs or is first discovered during pregnancy. With the economic development, lifestyle changes, the incidence of GDM is increasing year by year. GDM can lead to a series of maternal and child complications. Increased insulin resistance during pregnancy (GDM) is recognized as the main pathophysiological mechanism of GDM, but the specific mechanism of GDM is unknown. Recent studies have found that multifunctional ghrelin, Obestatin and Ghrelin, play an important role in obesity and energy metabolism,