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目的:观察中西医结合治疗乳腺癌肝转移的疗效及安全性,为乳腺癌肝转移的中西医结合治疗提供可参考的依据。方法:将42例乳腺癌肝转移患者随机分为治疗组与对照组各21例,对照组给予化疗、介入治疗、靶向治疗内分泌及西医护肝治疗,治疗组在对照组基础上加用中医外治中药内服治疗。用统计学方法从中医证候改善、KPS评分、治疗后缓解等方面,对治疗组和对照组的临床疗效进行比较分析,并记录患者远期生存率。结果:治疗组CR率与KPS评分明显优于对照组;治疗组总有效率71.43%,对照组总有效率为52.38%,两组比较差异具有统计学意义(P<0.05)。结论:中西医结合治疗较单纯西医治疗可延长乳腺癌肝转移患者的生存期,并减轻化疗、内分泌治疗、靶向治疗的毒副作用,提高患者的生活质量。
Objective: To observe the efficacy and safety of integrated traditional Chinese and western medicine in the treatment of liver metastases of breast cancer, and provide a reference for the treatment of breast-cancer with liver-metastasis. Methods: Forty-two patients with liver metastases from breast cancer were randomly divided into treatment group (21 cases) and control group (21 cases). The control group was treated with chemotherapy, interventional therapy, endocrine therapy and western medicine. The treatment group was treated with traditional Chinese medicine External treatment of Chinese medicine orally. Statistical methods from the TCM syndrome improved, KPS score, post-treatment remission and other aspects of the clinical efficacy of the treatment group and the control group were compared and recorded in patients with long-term survival. Results: The CR rate and KPS score of the treatment group were significantly better than those of the control group. The total effective rate was 71.43% in the treatment group and 52.38% in the control group. The difference between the two groups was statistically significant (P <0.05). Conclusion: The combination of TCM and WM can prolong the survival of patients with liver metastasis of breast cancer and relieve the toxic and side effects of chemotherapy, endocrine therapy and targeted therapy, and improve the quality of life of patients.