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目的探讨胃浸润性微乳头状癌(invasive micropapillary carcinoma,IMPC)的临床病理学特征。方法对1例胃IMPC进行组织学观察、免疫组化染色并复习相关文献。结果组织学及免疫表型符合典型IMPC,为早期胃癌,但出现多组淋巴结转移。免疫组化染色显示细胞团外周EMA阳性。临床ⅡA期,术后患者辅助化疗,随访17个月未见肿瘤复发及转移。结论胃IMPC属于胃腺癌的少见亚型,早期易出现淋巴结转移,临床预后还需积累更多样本进行进一步研究。
Objective To investigate the clinicopathological features of gastric invasive micropapillary carcinoma (IMPC). Methods One case of gastric IMPC was observed histologically, immunohistochemically and reviewed. Results Histology and immunophenotype were consistent with the typical IMPC, which was early gastric cancer, but there were multiple groups of lymph node metastases. Immunohistochemical staining showed that EMA was positive in cell periphery. Clinical stage ⅡA, postoperative adjuvant chemotherapy, no follow-up of 17 months tumor recurrence and metastasis. Conclusion Gastric IMPC belongs to the rare subtype of gastric adenocarcinoma. Lymph node metastasis is easy to occur in early stage. More samples need to be accumulated for further study in clinical prognosis.