A numerical model of the coupling between astronomical tide and storm surge based on Mike 21 is applied to the coastal regions of Zhejiang Province. The model is used to simulate high tide levels combined with storm surge during 5 typhoons, including two super typhoons, that landed in the Province. In the model, the atmospheric forcing fields are calculated with parametric wind and pressure models. The computational results, with average computed errors of 13 cm for the high astronomical tide levels and 20 cm for the high storm-tide levels, show that the model yields good simulations. Typhoon No. 5612, the most intense to land in China since 1949, is taken as the typical super typhoon for the design of 5 typhoon routes, each landing at a different location along the coast. The possible extreme storm-tide levels along the coast are calculated by the model under the conditions of the 5 designed typhoon routes when they coincide with the spring tide. Results are compared with the high storm-tide levels due to the increase of the central atmospheric pressure at the base of a typical super typhoon, the change of tidal type, and the behavior of a Saomai-type typhoon. The results have practical significance for forecasting and minimization of damage during super typhoons.