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多发性肌炎(皮肌炎)被认为是“自体免疫性疾病”之一。本病与系统性红斑狼疮,全身性硬皮病等免疫性疾病可同时存在,以及对醣类皮质素治疗有效均有力地支持这一论点。多发性肌炎曾被假定有抗肌组织循环自身抗体存在,有人试图用各种方法将其证实之。1963年Barwick等用鞣酸红细胞凝集法来测定循环自身抗体与琼脂扩散法一样始终未获成功;用免疫萤光法来测定与肌肉相结合的各种抗体,其结果为阳性或阴性者均有报导。为解释此种不一致的结果,Fessel等着重指出各种免疫球蛋白对横纹肌纤维组织具有牢固的非特异性亲和力。在多发性肌炎甚少有关于抗肌组织各种提纯成份循环自身抗体存在的报导。Caspary等首创用鞣酸红细胞
Polymyositis (dermatomyositis) is considered as one of the “autoimmune diseases”. The disease and systemic lupus erythematosus, systemic scleroderma and other immune diseases can coexist, as well as the effective treatment of glucocorticoid strongly support this argument. Polymyositis has been postulated to have autoantibodies to muscle tissue circulating and some have tried to confirm it with various methods. In 1963 Barwick and other tanning hemagglutination method to determine circulating autoantibodies and agar diffusion method has always been unsuccessful; immunofluorescence method to determine the combination of muscle antibodies, the results were positive or negative who have Reported. To explain this inconsistent result, Fessel et al highlighted that each immunoglobulin has strong nonspecific affinity for striated muscle fibers. In polymyositis few reports on the presence of circulating autoantibodies against various purified components of the muscle tissue. Caspary and other first use of tannic acid red blood cells