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目的探讨一种控制惊厥持续状态安全、有效的方法。方法将48例惊厥持续状态患儿随机分为异丙酚组(24例)和地西泮组(24例)。异丙酚组首剂给予3mg/kg,静脉推注后以90μg/(kg·min)持续静滴48h后根据惊厥情况逐渐减量至停用。地西泮组用地西泮注射液首剂0.3～0.5mg/(kg·min)的速度静脉推注,后以0.1～0.2mg/(kg·h)持续48h。观察两组患儿的药物起效时间、复发率、及预后。结果两组控制发作及起效时间无统计学差异(P>0.05),均起效迅速;异丙酚组的复发率较地西泮组低,差异具有统计学意义(P<0.05);从注药后计算苏醒时间,异丙酚组平均24h,而地西泮组42h,差异具有统计学意义(P<0.05)。结论静脉注射异丙酚控制惊厥持续状态效果佳,是较理想的抗惊厥药物。
Objective To explore a safe and effective method of controlling convulsions sustained state. Methods Forty-eight convulsions were randomly divided into propofol group (24 cases) and diazepam group (24 cases). Propofol group given the first dose of 3mg / kg, intravenous bolus 90μg / (kg · min) for 48h after intravenous infusion according to convulsions gradually tapering to disable. Diazepam group with the first dose of diazepam 0.3 ~ 0.5mg / (kg · min) rate of intravenous injection, followed by 0.1 ~ 0.2mg / (kg · h) for 48h. The onset time, relapse rate and prognosis of the two groups were observed. Results There was no significant difference between the two groups in onset of control and onset of onset (P> 0.05), with rapid onset of action. The recurrence rate of propofol group was lower than that of diazepam group (P <0.05) After injection, the awake time was calculated, and the difference was statistically significant (P <0.05) between the propofol group and the diazepam group for 42 hours. Conclusion Intravenous injection of propofol to control convulsions sustained effect is good, is an ideal anticonvulsant drug.