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目的研究肝炎康对大鼠慢性肝纤维化的保护作用及其机理。方法用CCl4和乙醇造成大鼠慢性肝纤维化模型,同时用肝炎康治疗,观察各组大鼠血清谷丙转氨酶(ALT)、谷草转氨酶(AST)活性、肝组织丙二醛(MDA)和羟脯氨酸(Hyp)含量,并观察肝组织病理变化。结果模型组血清ALT和AST明显高于空白对照组(P<0.01),MDA和Hyp含量高于空白对照组(P<0.01);肝组织病理切片显示肝组织正常结构被破坏,纤维组织明显增生,形成假小叶结构。与模型组比,用药组大鼠血清ALT、AST活性及肝组织Hyp、MDA含量明显降低(P<0.05或P<0.01);肝组织病理切片显示汇管区有少量纤维组织增生,但未见假小叶结构;肝纤维化程度明显降低。结论肝炎康对大鼠慢性肝纤维化具有明显的治疗作用。
Objective To study the protective effect of Heyankang on chronic liver fibrosis in rats and its mechanism. Methods Chronic hepatic fibrosis model was established in rats with CCl4 and ethanol. At the same time, Hepatitis was used to treat serum glutamic-pyruvic transaminase (ALT), aspartate aminotransferase (AST) activity, malondialdehyde (MDA) and hydroxyl in liver tissue. Proline (Hyp) content, and observe the pathological changes of liver tissue. Results Serum ALT and AST levels in the model group were significantly higher than those in the blank control group (P<0.01), and MDA and Hyp levels were higher than those in the blank control group (P<0.01). Histopathological examination of the liver showed that the normal structure of the liver tissue was destroyed and the fibrous tissue became hyperplasia. , Form false leaflet structure. Compared with the model group, serum ALT, AST activity and liver tissue Hyp, MDA content in the medication group were significantly reduced (P<0.05 or P<0.01); pathological section of the liver showed a small amount of fibrous tissue in the portal area, but no false Lobular structure; liver fibrosis was significantly reduced. Conclusion Hegan Kang has obvious therapeutic effect on chronic liver fibrosis in rats.