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目的观察丁丙诺啡透皮贴剂治疗中重度慢性疼痛的疗效和安全性。方法收集2015年10月至2016年3月在我院骨科门诊确诊为中重度慢性疼痛患者68例,给予丁丙诺啡透皮贴剂进行止痛治疗,初始剂量5 mg,qw,根据疼痛情况调整剂量至无痛或基本无痛状态。对每位患者随访1个月,分别评估患者治疗前后疼痛强度、镇痛效果、生活质量、用药依从性,同时监测药物不良反应。结果治疗前、后患者疼痛数字评分分别为(5.90±1.05)分和(1.35±0.75)分,P<0.05;疼痛总缓解率为91.18%;治疗后SF-36生活质量量表(中文版)8个方面维度分数和用药依从性均较治疗前显著提高(P<0.05);药物不良反应发生率为8.82%。结论丁丙诺啡透皮贴剂具有镇痛稳定、作用持久、不良反应轻、用药依从性高等特点,可倡导应用于中重度慢性疼痛的治疗。
Objective To observe the efficacy and safety of buprenorphine transdermal patch in the treatment of moderate-severe chronic pain. Methods Sixty-eight patients with moderate-to-severe chronic pain diagnosed in orthopedic clinic of our hospital from October 2015 to March 2016 were enrolled in this study. Buprenorphine transdermal patch was given for analgesic treatment. The initial dose was 5 mg, qw, adjusted according to the pain condition Dose to painless or almost painless condition. Each patient was followed up for 1 month, and the pain intensity, analgesic effect, quality of life and drug compliance were evaluated before and after treatment, and adverse drug reactions were monitored. Results The pain scores before and after treatment were (5.90 ± 1.05) and (1.35 ± 0.75) points respectively, P <0.05. The total pain relief rate was 91.18%. After treatment, the SF-36 quality of life scale (Chinese version) The dimensions of 8 dimensions and drug compliance were significantly higher than those before treatment (P <0.05). The incidence of ADR was 8.82%. Conclusion Buprenorphine transdermal patch has the characteristics of stable analgesic effect, long lasting effect, light adverse reaction and high medication adherence. It can be used in the treatment of moderate-severe chronic pain.