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目的:探讨重度、极重度COPD急性加重期合并多MODS临床特征和预后有关的危险因素。方法:回顾分析1999～2009年因重度、极重度COPD急性期合并多器官功能障碍而住院的患者临床资料。结果:本研究共纳入226例患者,平均年龄为69.3±5.2岁。呼吸系统功能障碍发生率最高,有200例。其次是心血管功能障碍和中枢神经功能障碍,各102例。患者的病死率随着器官功能障碍的数目增加而增加。结论:治疗重度、极重度COPD急性加重时,在常规治疗基础的同时防治MODS是降低患者病死率的关键。
Objective: To investigate the clinical characteristics and prognosis-related risk factors of severe and severe COPD in acute exacerbation combined with MODS. Methods: The clinical data of patients hospitalized for severe and severe acute COPD with multiple organ dysfunction from 1999 to 2009 were retrospectively analyzed. Results: A total of 226 patients were enrolled in this study, with an average age of 69.3 ± 5.2 years. The highest incidence of respiratory dysfunction, 200 cases. Followed by cardiovascular dysfunction and central nervous system dysfunction, the 102 cases. Patient mortality increases with the number of organ dysfunction. Conclusions: In the treatment of severe and very severe acute exacerbations of COPD, the prevention and treatment of MODS is the key to reduce the mortality of patients.