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目的 观察立体定向放射治疗 (SRT )应用于脑胶质瘤患者治疗的疗效。方法 采用SRT治疗 41例脑胶质瘤患者 ,其中初治患者 3 0例 ,复发者 11例。单次治疗 (SRS) 3 2例 ,分次治疗 (FSRS) 9例。SRS和FSRS的中位靶区周边剂量分别为 2 0Gy和 3 6Gy。 2 6例SRS和 8例FSRS患者分别接受中位剂量为 40Gy和 3 0Gy的外照射。中位随访期为 2 2个月 ( 9～ 3 4个月 )。结果 全组局部病灶控制率为 63 .4%,中位生存期 (MST )为 11.5个月 ,其中SRS和FSRS组MST分别为 11和 16.5个月 ;初治和复发者MST分别为 17和 8.5个月。全组 1年和 2年生存率分别为 5 4%和 3 4 %。结论 SRT可加强局部病灶控制 ,对瘤体较小、边界清晰的胶质瘤可作为 1种安全有效的辅助治疗手段。
Objective To observe the effect of stereotactic radiotherapy (SRT) on glioma patients. Methods 41 patients with glioma were treated with SRT, including 30 newly diagnosed patients and 11 relapsed patients. There were 32 cases of single treatment (SRS) and 9 cases of fractional treatment (FSRS). The median target dose for SRS and FSRS was 20 Gy and 36 Gy, respectively. Twenty-six SRS and eight FSRS patients received median doses of 40 Gy and 30 Gy, respectively. The median follow-up period was 22 months (range, 9 to 34 months). Results The overall control rate of local lesions was 63.4%, and the median survival time (MST) was 11.5 months. The MST in SRS and FSRS groups were 11 and 16.5 months respectively. The initial treatment and relapsers MST were 17 and 8.5 Months. The 1-year and 2-year overall survival rates were 54% and 34% respectively. Conclusion SRT can enhance the control of local lesion. It can be used as a safe and effective adjuvant treatment for gliomas with small tumor size and clear border.