目的　报告单鼻孔直接经蝶窦入路切除垂体腺瘤 32例显微手术的运用经验 ,并与其它经蝶入路进行比较。方法　将扩张器插入手术侧鼻孔 (通常采用右侧 )直抵蝶窦前壁进行扩张 ,显露蝶窦开口 ,凿开前壁 ,进行手术。结果　 31例肿瘤近全切除 ,1例大部切除。1例术后脑脊液鼻漏。结论　此入路与其它经蝶切除鞍区病变的术式相比 ,对鼻部组织损伤小 ,不必分离鼻中隔和两侧粘膜 ,省时 ,简单 ,并发症少 ,值得临床推广 Objective To report the experience of microsurgery in the treatment of pituitary adenoma by single nostril direct transsphenoidal approach and compare with other transsphenoidal approaches. Methods The dilator was inserted into the nostril on the operation side (usually on the right) until the anterior wall of the sphenoid sinus was dilated to expose the sphenoid sinus. The anterior wall was opened and the operation was performed. Results 31 cases of tumor near total resection, 1 case of partial resection. One case of postoperative cerebrospinal fluid rhinorrhea. Conclusion Compared with other surgical methods of transection of sellar region by transsphenoidal approach, this approach has less damage to the nasal tissue and no need to separate nasal septum and mucosa on both sides. It is time-saving and simple with few complications and is worthy of clinical promotion