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【动态】干细胞和祖细胞通过调节增殖和分化之间的平衡来维持他们所在组织的正常性,但还不清楚他们是如何做到这一点的。美国科学家最近报告人体细胞外体(exosome,是大约11种蛋白质组成的复合体)负责降解和循环利用各种磨损或出错的RNA,作为细胞的监视系统调控RNA的正常运转,维持祖细胞的功能。在表皮祖细胞中发现细胞外体的几个亚基的表达加强了,这是保持增殖能力和预防提前分化所必须的。细胞外体蛋白复合物的一个关键亚基PM/Scl-75(亦称EXOSC9)的缺失将导致祖细胞池中祖细胞数量的减少、提前分化以及表
[Dynamic] Stem cells and progenitor cells maintain the normality of their tissues by regulating the balance between proliferation and differentiation, but it is unclear how they did that. Recently, scientists in the United States reported that exosomes (a complex of about 11 proteins) are responsible for the degradation and recycling of various abraded or erroneous RNAs as a cell monitoring system to regulate the normal operation of RNA and maintain the function of progenitor cells . The expression of several subunits of extracellular bodies was found to be increased in epidermal progenitors, which is necessary to maintain proliferative capacity and prevent premature differentiation. The absence of PM / Scl-75 (also known as EXOSC9), a key subunit of the extracellular body protein complex, will result in a reduction in the progenitor cell population in progenitor cells, premature differentiation,