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用ＤＮＡ－ｍＲＮＡ原位杂交法测定ｒｈ－ＴＧＦ－β对１１例血液病患者骨髓有核细胞的部分癌基因和细胞因子基因ｍＲＮＡ表达的影响。结果呈明显的个体差异。用ＡＢＣ免疫酶标法测定ｒｈ－ＴＧＦ－β对１０例脐带血白细胞和２２例血液病患者骨髓有核细胞ＨＬＡ－Ⅱ类抗原表达的影响。结果表明：ｒｈ－ＴＧＦ－β对ＨＬＡ－ＤＱ抗原表达可有下调作用。
The effect of rh-TGF-β on the expression of some oncogenes and cytokines mRNA in bone marrow nucleated cells of 11 patients with hematological diseases was determined by DNA-mRNA in situ hybridization. The results showed obvious individual differences. The effect of rh-TGF-β on the expression of HLA-Ⅱ antigen in bone marrow nucleated cells of 10 cases of umbilical cord blood leukocytes and 22 cases of hematological diseases was determined by ABC immunohistochemical method. The results showed that rh-TGF-β could down-regulate HLA-DQ antigen expression.