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抗肿瘤药N-甲酰溶肉瘤素(简称N-甲)的毒性低.小鼠于每天口服25-150毫克/公斤连续10天,游泳耐力不减,肝脏破坏戊巴比妥钠功能正常.小鼠于腹腔注射N-甲10-20毫克/公斤/天,连续10天,或150毫克/公斤一次,对因戊巴比妥钠产生的睡眠时间无改变.大鼠于每天腹腔注射N-甲10毫克/公斤,连续10天,其利尿功能,肾上腺内维生素C含量及微血管渗进性均无明显改变.麻醉兔于静脉注射N-甲10-40毫克/公斤后,血压亦无明显改变.当N-甲20毫克/公斤/天,连续10天时,于注射后5天,大鼠利尿功能受到抑制,但于停药后3天逐渐恢复正常.大鼠于腹腔注射N-甲80毫克/公斤后2小时,肾上腺内维生素C含量明显下降,微血管渗透性显著增加.
The anti-tumor drug N-formylcystein (referred to as N-methyl) low toxicity mice daily oral 25-150 mg / kg for 10 consecutive days, swimming endurance diminished liver destruction of pentobarbital sodium function properly. Mice were intraperitoneally injected with N-methyl 10-20 mg / kg / day for 10 consecutive days, or 150 mg / kg once, for the pentobarbital sodium-generated sleep time unchanged rats were intraperitoneally injected N- A 10 mg / kg for 10 consecutive days, its diuretic function, adrenal vitamin C content and microvascular infiltration were no significant changes in anesthetized rabbits intravenous injection of N-methyl 10-40 mg / kg, no significant change in blood pressure When N-methyl 20 mg / kg / day for 10 consecutive days, 5 days after injection, the diuretic function of rats was inhibited, but gradually returned to normal 3 days after the withdrawal.A rat was injected intraperitoneally with N- After 2 hours / kg, the content of vitamin C in the adrenal glands decreased significantly, and the microvascular permeability increased significantly.