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目的探讨高危型HPV检测在宫颈上皮内瘤变LEEP术后疗效及随访监测中的临床意义。方法我院活检确诊的50例子宫上皮内瘤变(CIN)患者,根据检查结果将其分为CINⅠ组和CINII～Ⅲ组(不含原位癌),实施宫颈环行电圈切除术(LEEP),术前、术后进行HPV-DNA检测,平均随访1年,对其临床疗效进行观察和比较。结果 CINⅠ组转阴率为83.3%,CIN II～Ⅲ组的转阴率为69.2%;CINⅠ组治愈15例(93.8%),CIN II～Ⅲ组治愈31例(91.2%);平均随访1年,仍有4例病变,其中2例CIN I、1例CIN II、1例CIN III,均为HPV-DNA阳性。结论 HPV能够准确反应宫颈上皮内瘤变LEEP术后临床疗效,作为随访检测手段,指导进一步治疗。
Objective To investigate the clinical efficacy of high-risk HPV testing in the treatment of cervical intraepithelial neoplasia (LEEP) and follow-up monitoring. Methods Fifty patients with intrauterine uterine intraepithelial neoplasia (CIN) diagnosed by biopsy in our hospital were divided into CINⅠ group and CINII - Ⅲ group (without carcinoma in situ) according to the results of the examination. Cervical ring electrosurgical excision (LEEP) Preoperative and postoperative HPV-DNA tests were followed up for 1 year on average. The clinical effects were observed and compared. Results The negative conversion rate was 83.3% in CINⅠgroup and 69.2% in CINⅡ ~ Ⅲgroup, 15 cases (93.8%) in CINⅠgroup and 31 cases (91.2%) in CINⅡ ~ Ⅲgroup, with a mean follow-up of 1 year , There are still 4 cases of lesions, of which 2 cases of CIN I, 1 case of CIN II, 1 case of CIN III, are HPV-DNA positive. Conclusion HPV can accurately reflect the clinical effect of LEEP after cervical intraepithelial neoplasia. As a follow-up test, HPV can guide further treatment.