肺癌的常规化疗效果差 ,特别是复发性肿瘤 ,常产生对原化疗药物和其他药物的多药耐药性。已有的研究表明 ,恶性肿瘤及其耐药细胞存在遗传不稳定性。这些遗传不稳定性导致了肿瘤及其耐药性的产生。遗传不稳定性以微卫星不稳定性和染色体不稳定性两种形式存在。其中 ,染色体不稳定性具体表现为染色体数目的改变和染色体结构的改变。 Conventional chemotherapy in lung cancer is poor, especially recurrent tumors, often produce multi-drug resistance to the original chemotherapy drugs and other drugs. Some studies have shown that there is genetic instability in malignant tumors and their resistant cells. These genetic instability leads to the development of tumors and their resistance. Genetic instability exists in both microsatellite instability and chromosomal instability. Among them, chromosome instability is manifested in the change of chromosome number and chromosome structure.