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目的:观察丹参多酚酸盐联合低分子肝素治疗高原地区原发性肾病综合征的临床疗效。方法:46例原发性肾病综合征患者随机分为对照组与治疗组各23例。对照组予常规治疗,治疗组在此基础上加用丹参多酚酸盐100 mg,ivd,qd及低分子肝素5 000 IU,皮下注射,bid。连用2周。观察两组患者治疗前后尿量、体质量、24 h尿蛋白、血清白蛋白(ALB)、三酰甘油(TG)、总胆固醇(TC)、血红蛋白(Hb),凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB),D-二聚体(D-D)等变化。结果:与对照组相比,治疗组2周后尿量明显增加、体质量明显下降;24 h尿蛋白明显减少,ALB和Hb增加,TG和TC明显下降;PT、APTT明显延长、FIB和D-D明显下降(P<0.05或0.01)。结论:丹参多酚酸盐联合低分子肝素治疗可明显增加患者尿量,降低体质量,提高血清白蛋白和血红蛋白,降低血脂,改善患者的高凝状态,对高原地区原发性肾病综合征具有良好的治疗作用。
Objective: To observe the clinical efficacy of Salviae miltiorrhizae polyphenols combined with low molecular weight heparin in the treatment of primary nephrotic syndrome in the plateau area. Methods: 46 patients with primary nephrotic syndrome were randomly divided into control group and treatment group, 23 cases each. The control group was given conventional treatment. On the basis of this, the treatment group was given salvianolate 100 mg, ivd, qd and low molecular weight heparin 5000 IU, subcutaneously, bid. For two weeks. The changes of urine volume, body weight, 24 h urine protein, ALB, TG, TC, Hb, PT, Activated partial thromboplastin time (APTT), fibrinogen (FIB), D-dimer (DD) and other changes. Results: Compared with the control group, the urine volume of the treatment group increased significantly after 2 weeks and the body weight decreased significantly. Urine protein decreased significantly at 24 h, ALB and Hb increased, while TG and TC decreased significantly. PT and APTT prolonged significantly. FIB and DD Decreased significantly (P <0.05 or 0.01). Conclusion: Radix Salviae miltiorrhizae combined with low molecular weight heparin can significantly increase the urine volume, reduce body weight, raise serum albumin and hemoglobin, reduce blood fat and improve the hypercoagulability in patients with primary nephrotic syndrome in the plateau region Good therapeutic effect.