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本文报道了骨结核病手术治疗缓释植入型药物异烟肼明胶海绵的制备,放射性同位素示踪技术的药代动力学和药物毒副乍用的研究结果:表明该剂型能在植入部位通过缓慢释放而高效的发挥异烟肼的抗结核菌作用,并具有促进手术后骨洞内血液循环,有利骨膜形成和无毒副反应的特点,它的临床应用将有效地防止骨结核的复发,为根治骨结核病发挥作用.
This article reports the preparation of sustained-release implantable drug isoniazid gelatin sponge for surgical treatment of bone tuberculosis. The pharmacokinetics and drug toxicity of radioisotope tracer technology were studied. The results show that the dosage form can pass through the site of implantation Slowly release and effectively play the role of isoniazid anti-TB, and has the effect of promoting postoperative blood circulation in the cave, favorable periosteal formation and non-toxic side effects, its clinical application will effectively prevent the recurrence of bone tuberculosis, To cure bone tuberculosis play a role.