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目的探讨性母细胞瘤的临床病理特征、肿瘤的性质和生物学行为。方法采用光镜、免疫组化对3例性母细胞瘤进行观察,并复习相关文献。结果3例患者分别表现为停经及不规则阴道出血、原发性闭经和盆腔包块。组织学上主要由两种细胞组成,一种为类似于无性细胞瘤及精原细胞瘤的生殖细胞,另一种为与未成熟的睾丸支持细胞或颗粒细胞相似的性索间质细胞。肿瘤细胞呈巢状分布,分为冠状结构及微滤泡结构。3例均表现为无性细胞过度生长形成无性细胞瘤伴钙化。1例检测到Y染色体。结论性母细胞瘤是一种罕见的混合性生殖-性索间质肿瘤,具有独特的病理形态特征。它属于原位生殖细胞肿瘤,具有恶性转化的潜能。
Objective To investigate the clinicopathological characteristics, the nature of the tumor and the biological behavior of the human blastoma. Methods Using light microscope and immunohistochemistry, 3 cases of blastoblastoma were observed, and the related literatures were reviewed. Results The three patients showed menopause and irregular vaginal bleeding, primary amenorrhea and pelvic mass. Histologically, there are mainly two kinds of cells, one is germ cell similar to dysgerminoma and seminoma and the other is interstitial mesenchymal cells similar to immature testes supporting cells or granulosa cells. Tumor cells were nested distribution, divided into coronary and micro-follicular structure. 3 cases showed the phenomenon of clonal growth of asexual cells with calcification. One case detected the Y chromosome. Conclusions Blastocyst is a rare mixed reproductive-sex cord stromal tumor with unique pathological features. It is an in situ germ cell tumor with the potential for malignant transformation.