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为观察胰岛素样生长因子－ １ （ＩＧＦ－ １） 的致纤维化作用， 采用免疫组化技术观察了染尘后不同时期兔肺组织ＩＧＦ－ １ 表达水平和支气管肺泡灌洗术（ＢＡＬ） 对肺纤维化的影响。结果表明， 染尘后１８０ 天组动物肺组织ＩＧＦ－ １ 表达强度显著高于染尘后９０ 天组动物（ Ｐ＜ ０－０１） ， 灌洗组动物肺组织ＩＧＦ－ １ 表达强度及肺纤维化程度明显轻于未灌洗组动物。提示ＩＧＦ－ １ 在矽肺纤维化形成和维持过程中发挥着重要作用
To observe the fibrotic effect of insulin-like growth factor-1 (IGF-1), the expression of IGF-1 in lung tissue and bronchoalveolar lavage (BAL) Effect of fibrosis. The results showed that the expression level of IGF-1 in lung tissue of the animals 180 days after dying was significantly higher than that of the animals on the 90th day after dying (P <0-01). The expression of IGF-1 in the lung tissue and pulmonary fibrosis Degree was significantly lighter than non-lavaged animals. Tip IGF-1 plays an important role in the formation and maintenance of silicosis