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目的 :选用中药“治晕灵”的主要成分生姜、明天麻等六味草药煎成汤剂、或半量汤剂配西药脑益嗪、山莨菪碱各1 4临床常用量配成复方中西药制剂 ,与目前常用抗晕药晕海宁等中、西药的药效进行比较 ,看中药制剂或中西药复方制剂是否具有较好的抗运动病效果。方法 :选 7名敏感被试者 (女性 ,19~ 2 1岁 ) ,用旋转刺激诱发运动病至出现恶心。按拉丁方设计 ,与安慰剂 (淀粉 10 0mg)及晕海宁 (5 0mg)进行对比 ,分别观察了生姜合剂 (30ml)、晕可平 (30ml)、山莨菪碱 (10mg)、脑益嗪 (2 5mg)及上述复方中西药制剂口服后的运动病耐力。结果 :与安慰剂比较 ,晕海宁、山莨菪碱、脑益嗪、晕可平、生姜合剂、复方中西药制剂分别使运动病耐力提高 5 .4%、7.5 %、5 .9%、7.4%、32 .3 %、2 0 .4% ;生姜合剂效果较优 ,除口服时有辛辣味外 ,无明显的副作用。复方中西药制剂各成分未显示协同作用 ,而只是简单的作用相加。结论 :生姜合剂具有较好的抗运动病作用
Objective: To select the traditional Chinese medicine “cure Halo” the main ingredient of ginger, Tomoka and other herbs Liu Jian Tang Decoction, or a half amount of decoction with Western medicine brain Yizi, anisodamine each of the commonly used amount of 14 dubbed compound Chinese and Western medicine, With the current commonly used anti-halo Halide Haining, etc., the efficacy of Western medicine compared to see Chinese medicine or Chinese medicine compound preparations have better anti-motion sickness effect. Methods: Seven sensitive subjects (female, 19 to 21 years old) were selected and their nausea was induced by rotational stimulation. According to the Latin square design, compared with placebo (starch 100 mg) and halo Haining (50 mg), the effects of ginger mixture (30ml), haloperidol (30ml), anisodamine (10mg) 2 5mg) and the compound Chinese and Western medicine after oral administration of motion sickness endurance. Results: Compared with the placebo, halo Haining, anisodamine, brain Yizheng, Haloxapine, ginger mixture, compound Chinese and Western medicines increased the endurance of motion sickness by 5.4%, 7.5%, 5.9%, 7.4% , 32.3%, 20.4%; ginger mixture better, except when spicy taste, no obvious side effects. Compound Chinese and Western medicine ingredients did not show synergy, but only a simple additive effect. Conclusion: Ginger mixture has good anti-motion sickness