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目的探讨外周血单核细胞数量以及基质金属蛋白9和2(MMP9和MMP2)的水平与冠状动脉狭窄程度的相关性。方法连续入选经冠状动脉CT检查的患者434例,根据CT结果分为冠脉无狭窄、狭窄度<50%、狭窄度50-70%及狭窄度>70%四组。血常规检测单核细胞数量,ELISA检测MMP9和MMP2的水平。结果外周血单核细胞数量与冠脉狭窄程度明显相关,是冠脉狭窄程度的独立预测因子,受试者工作曲线(ROC)分析显示单核细胞数量大于0.4×109预测严重冠脉狭窄的灵敏度和特异度分别为62%和58%,联合性别和年龄可增加其预测能力。而MMP2和MMP9与冠脉狭窄程度则无显著相关性。结论外周血单核细胞数量是严重冠脉狭窄的预测因子,提示临床上可以使用一种简便、快捷、低价格的检测协助判断冠脉病变进展的程度。
Objective To investigate the relationship between the number of peripheral blood mononuclear cells and the levels of matrix metalloproteinases 9 and 2 (MMP9 and MMP2) and the degree of coronary artery stenosis. Methods A total of 434 consecutive patients undergoing CT coronary angiography were divided into four groups according to CT results: no coronary stenosis, less than 50% stenosis, 50-70% stenosis, and 70% stenosis. Blood mononuclear cells were detected by ELISA and MMP9 and MMP2 were detected by ELISA. Results The number of peripheral blood mononuclear cells was significantly correlated with the degree of coronary artery stenosis and was an independent predictor of the degree of coronary artery stenosis. The receiver operating characteristic curve (ROC) analysis showed that the number of mononuclear cells greater than 0.4 × 109 predicted the sensitivity of severe coronary artery stenosis And specificity of 62% and 58%, respectively, and gender and age increased their predictive power. There was no significant correlation between MMP2 and MMP9 and coronary stenosis. Conclusion The number of peripheral blood mononuclear cells is a predictor of severe coronary stenosis, suggesting that a simple, rapid and inexpensive test can help to determine the extent of coronary artery lesion in clinic.