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目的探讨智能银凝胶治疗外阴阴道假丝酵母菌种病(VVC)的有效性和安全性。方法采用多中心、随机性、双盲对照的研究方法,将2010年10月至2012年10月本县妇幼保健院就诊的并确诊的140例外阴阴道假丝酵母菌种病患者随机分为A组、B组、C组,均连续用药7 d,分别于用药后1周、1个月进行临床疗效评价、白带常规和复发率比较。结果 3组患者治疗前基础情况比较,差异无统计学意义(P>0.05);A、B两组临床疗效差异无统计学意义,但C组相对于A、B两组效果明显,差异有统计学意义(P<0.05)。结论智能银和克霉唑联合应用治疗外阴阴道假丝酵母菌种病疗效好,可以作为治疗VVC的一个新的联合治疗方案。
Objective To investigate the efficacy and safety of silver silver gel in the treatment of vulvovaginal candidal disease (VVC). Methods A multicenter, randomized, double-blind, controlled study was conducted in 140 cases of vulvovaginal Candida species that were diagnosed in MCH from October 2010 to October 2012. The patients were randomly divided into A Group B, Group C, were continuous medication 7 d, respectively, after 1 week, 1 month for clinical efficacy evaluation, routine and recurrence rate of leucorrhea. Results There was no significant difference in the basic situation between the three groups before treatment (P> 0.05). There was no significant difference in the clinical efficacy between the two groups (A and B), but there was significant difference between the two groups Significance (P <0.05). Conclusion The combination of smart silver and clotrimazole for the treatment of vulvovaginal candidiasis is effective and can be used as a new combination regimen for the treatment of VVC.