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目的探讨慢性阻塞性肺疾病(COPD)患者血浆中同型半胱氨酸(Hcy)在COPD发病机制中所起的作用,并观察其与肺功能是否具有相关性,及其与吸烟的关系。方法将研究对象分为2组,56例COPD患者作为观察组,43例健康体检者作为对照组,均检测血浆同型半胱氨酸、作肺功能(测定FEV1%预计值,FEV1/FVC)及肺CT检查。结果观察组血浆Hcy浓度为23.12(s=10.02)μmol/L,对照组血浆Hcy浓度9.23(s=5.16)μmol/L,2组相比差异有统计学意义(P<0.01);观察组随着FEV1%预计值的下降,血浆Hcy浓度逐渐升高,2者呈负相关(r=-0.46);观察组中吸烟者血浆Hcy浓度为28.68(s=12.61)μmol/L,而非吸烟者血浆Hcy浓度为18.91(s=5.27)μmol/L,2者比较差异有统计学意义(P<.05),对照组中吸烟者血浆Hcy浓度为10.15(s=6.16)μmol/L,非吸烟者血浆Hcy浓度为8.69(s=5.05)μmol/L,2者比较差异无统计学意义(P>0.05)。结论 COPD患者血浆Hcy浓度明显升高,且与COPD严重程度呈负相关,吸烟可导致血浆Hcy浓度升高。
Objective To investigate the role of plasma homocysteine (Hcy) in the pathogenesis of COPD in patients with chronic obstructive pulmonary disease (COPD) and to observe whether there is a correlation between it and lung function and its relationship with smoking. Methods The subjects were divided into two groups: 56 patients with COPD as observation group and 43 healthy subjects as control group. Plasma homocysteine levels were measured for pulmonary function (FEV 1% predicted, FEV 1 / FVC) and Lung CT examination. Results The plasma concentration of Hcy was 23.12 (s = 10.02) μmol / L in the observation group and the plasma Hcy concentration was 9.23 (s = 5.16) μmol / L in the control group. The difference between the two groups was statistically significant (P <0.01) The predictive value of FEV1% decreased, plasma Hcy concentration gradually increased, and the two showed a negative correlation (r = -0.46). The Hcy concentration of smoker in the observation group was 28.68 (s = 12.61) μmol / L, Plasma Hcy concentration was 18.91 (s = 5.27) μmol / L, the difference between the two groups was statistically significant (P <.05). The plasma concentration of Hcy in the control group was 10.15 (s = 6.16) μmol / The plasma Hcy concentration was 8.69 (s = 5.05) μmol / L, there was no significant difference between the two groups (P> 0.05). Conclusions Plasma homocysteine levels in patients with COPD were significantly increased, and negatively correlated with the severity of COPD. Smoking increased the plasma Hcy levels.