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以对羟基苯甲醛、硫酸二甲酯为原料,通过烷基化、还原两步反应合成对甲氧基苯甲醇,控制烷基化反应在碱性条件下进行,硫酸二甲酯与对羟基苯甲醛的摩尔比控制在1.02~1.04之间,还原反应选用水作为反应溶剂,并选用硼氢化钠作为催化剂,操作条件温和。两步反应结果显示,对甲氧基苯甲醇的含量为98.4%,总产率为79.8%。该合成工艺操作简单、原料价格优势明显、成本可控,适合工业化放大生产。
Using p-hydroxybenzaldehyde and dimethyl sulfate as raw materials, p-methoxybenzyl alcohol was synthesized through two steps of alkylation and reduction, and the alkylation reaction was controlled under basic conditions. The reaction between dimethyl sulfate and p-hydroxybenzene Formaldehyde molar ratio control between 1.02 ~ 1.04, the reduction reaction using water as a reaction solvent, and the use of sodium borohydride as a catalyst, mild operating conditions. The two-step reaction showed that the p-methoxybenzyl alcohol content was 98.4% and the total yield was 79.8%. The synthesis process is simple, obvious advantages of raw material prices, cost controllable, suitable for industrialized amplification.