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顺铂(DDP)是临床上常用的最有效的化疗药物之一,其在多种实验中显示的致突变性、致癌性日益受到人们的关注。近年来对茶多酚(TP)的研究[1]表明,TP具有抗氧化、抗突变、促进DNA修复等多种生物活性。本文通过动物实验从遗传及肾毒性方面探讨TP对DDP致机体损害的影响。1 材料与方
Cisplatin (DDP) is one of the most effective chemotherapy drugs commonly used clinically. Its mutagenicity and carcinogenicity have been attracting more and more attention in many experiments. In recent years, the study of tea polyphenols (TP) [1] showed that TP has many biological activities such as anti-oxidation, anti-mutation and DNA repair. In this paper, animal experiments from the genetic and nephrotoxicity of TP on DDP induced body damage. 1 material and side