Chimonanthus plants widely distributed in southern area of China,which have a long history of edibles and medicine.Phytochemical investigations have shown that Chimonanthus produced 143 non-volatile constituents,including alkaloids,flavonoids,terpenoids,coumarins and others,which exhibit significant anti-oxidant,anti-bacterial,anti-cancer,anti-inflammatory,antihyperglycemic,antihyperlipidemic and other biological activities.On the basis of systematic reviewing of literatures,this article overviews the non-volatile constituents and pharmacology of Chimonanthus from domestic and foreign over the last 30 years (until June 2018),and may provide a useful reference for the further development of Chimonanthus.