作者报告棉酚抑制LH,8-溴代C-AMP引起的睾酮生成,也抑制大鼠离体间质细胞内孕烯醇酮转化为睾酮。用棉酚处理大鼠一周后血清睾酮水平也显著降低。认为棉酚所引起的男性无精子和少精子可能是继发于睾酮生物合成的降低。用精制醋酸棉酚,对从60—90天的Sp- The authors report that gossypol inhibits testosterone production by LH, 8-bromo-C-AMP and also inhibits the conversion of pregnenolone to testosterone in isolated rat interstitial cells. Serum testosterone levels were also significantly reduced after rats were treated with gossypol for one week. It is believed that gossypol induced male azoospermia and oligospermia may be secondary to the decrease of testosterone biosynthesis. With refined gossypol acetate, from 60-90 days of Sp-