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目的 探讨洛赛克、克拉仙、阿莫仙三联短程疗法根除儿童幽门螺杆菌 (HP)现症感染的疗效。方法 经13C尿素呼吸试验 (13C -UBT)及血清HP -IgG测定 2项阳性的反复腹痛患儿 6 3例 ,分为治疗组 36例与安慰剂组 2 7例。治疗组接受洛赛克、克拉仙、阿莫仙三联治疗 ,安慰剂组口服安慰剂 ;疗程均为 1周。停药后 4周门诊复诊并复查13C -UBT。结果 治疗组与安慰剂组临床总有效率分别为 10 0 %和 2 2 2 % ,HP根除率分别为83 3 %和 11 1%。结论 部分小儿反复腹痛与HP现症感染密切相关 ;洛赛克、克拉仙、阿莫仙三联 1周短程疗法根除反复腹痛儿童HP现症感染临床效果好 ,HP根除率高 ,副作用少
Objective To explore the curative effect of triple therapy of Losec, Klasen and Almoria in eradicating the infection of Helicobacter pylori in children. Methods Sixty-three children with positive recurrent abdominal pain were measured by 13C urea breath test (13C-UBT) and serum HP-IgG, which were divided into treatment group (36 cases) and placebo group (27 cases). The treatment group received triple therapy with Losec, Klasen and Amoxicillin, and the placebo group with oral placebo. The course of treatment was 1 week. Four weeks after discontinuation of the clinic referral and review 13C -UBT. Results The total effective rates of the treatment group and the placebo group were 100% and 222% respectively, and the HP eradication rates were 83.3% and 11.1% respectively. Conclusions Some recurrent abdominal pains in children are closely related to the infection of the present HP. One week short-course therapy of Losec, Claxian and Amoxicillin is effective in eradicating the infection of HP with recurrent abdominal pain. The HP eradication rate is high and the side effects are few