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目的：观察脂肪乳剂对危重早产儿动脉血气的影响。方法：将４０例患有肺炎等疾病的危重早产儿随机分成四组，其中１组不给予脂肪乳剂作为对照，另３组分别按每天每千克体重给予１０％Ｉｎｔｒａｌｉｐｉｄ１、２和３ｇ，连续５天。在实验前和结束时分别作血脂测定和动脉血气分析。结果：动脉血气分析示各组实验后与实验前比较无显著差异，应用脂肪乳剂１．０、２．０、３．０ｇ／（ｋｇ·ｄ）后各实验组与对照组比较差异亦不显著，仅在３．０ｇ／（ｋｇ·ｄ）组显示ＰａＯ２和ＳａＯ２有下降的趋势。血脂分析示仅在实验后３．０ｇ／（ｋｇ·ｄ）组总胆固醇比实验前显著增高，甘油三酯显著高于对照组。结论：在危重早产儿应用脂肪乳剂１～３ｇ／（ｋｇ·ｄ）对血气无显著影响，但仍提出在危重早产儿应用脂肪乳剂时仍应注意监测肺功能有关指标，如动脉血气分析。
Objective: To observe the effect of fat emulsion on arterial blood gas in critically ill premature infants. Methods: Forty critically ill preterm infants with pneumonia and other diseases were randomly divided into four groups. One group received no fat emulsion as a control. The other three groups received 10% Intralipid 1, 2 and 3 g / kg body weight daily for 5 consecutive days . Lipid determination and arterial blood gas analysis were done before and at the end of the experiment. Results: Arterial blood gas analysis showed that there was no significant difference between the experimental group and the experimental group after the experiment. There was no significant difference between the experimental group and the control group with 1.0, 2.0, 3.0 g / (kg · d) , Only 3.0g / (kg · d) group showed PaO2 and SaO2 have a downward trend. Lipid analysis showed that total cholesterol in the 3.0g / (kg · d) group was significantly higher than that before the experiment and triglyceride was significantly higher than that in the control group only after the experiment. CONCLUSIONS: The use of 1 to 3 g / (kg · d) fat emulsion in critically ill preterm infants has no significant effect on blood gas, but it is still suggested that the use of fat emulsion in critically ill preterm infants should pay attention to monitoring pulmonary function indicators such as arterial blood gas analysis.