论文部分内容阅读
目的:观察大柴胡汤加减联合西药治疗重症急性胰腺炎的临床疗效。方法:100例重症急性胰腺炎患者,随机分为对照组和观察组,各50例。对照组采用乌司他丁联合奥曲肽治疗;观察组在对照组治疗基础上采用大柴胡汤加减治疗,比较2组临床疗效,观察2组治疗前后肿瘤坏死因子-α(TNF-α)、白细胞介素-2(IL-2)、白细胞介素-6(IL-6)及白细胞介素-8(IL-8)水平。结果:观察组治疗后腹痛缓解时间、首次排便时间、血淀粉酶恢复正常时间以及住院时间,均显著短于对照组,与对照组比较,差异有统计学意义(P<0.05)。2组治疗后TNF-α、IL-2、IL-6及IL-8水平均有改善,与本组治疗前比较,差异有统计学意义(P<0.05);观察组治疗后TNF-α、IL-2、IL-6及IL-8水平与对照组比较,差异有统计学意义(P<0.05)。结论:大柴胡汤加减联合西药治疗重症急性胰腺炎能明显缩短临床症状改善时间,改善炎性指标,值得推广应用。
Objective: To observe the clinical effect of Dachaihu Decoction combined with western medicine in the treatment of severe acute pancreatitis. Methods: One hundred patients with severe acute pancreatitis were randomly divided into control group and observation group, with 50 cases each. The control group was treated with ulinastatin combined with octreotide. The observation group was treated with Dachaihu Decoction on the basis of the control group, and the clinical curative effect was compared between the two groups. The levels of tumor necrosis factor-α (TNF-α), leukocyte (IL-2), interleukin-6 (IL-6) and interleukin-8 (IL-8) Results: The pain relieving time, defecation time, blood amylase recovery time and hospital stay in the observation group were significantly shorter than those in the control group after treatment. The difference was statistically significant (P <0.05). The levels of TNF-α, IL-2, IL-6 and IL-8 in the two groups were improved after treatment, which were significantly different from those before treatment in the two groups (P <0.05) IL-2, IL-6 and IL-8 levels compared with the control group, the difference was statistically significant (P <0.05). Conclusion: Dachaihu Decoction combined with Western medicine in the treatment of severe acute pancreatitis can significantly shorten the time to improve clinical symptoms and improve the inflammatory index, which is worth popularizing and applying.