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由于2(5-H)-呋喃酮的组份广泛地存在于具有生理活性的天然产物中,以及被用作有机合成的中间体,近年来,有机化学界对Υ-取代基α,β-不饱和丁烯内酯的合成和结构性能的研究给以极大的兴趣和关注。我们新近报道了新的手性源5-(1-(?)氧基)-3,4-二氯-2(5-H)-呋喃酮的合成及结构。本文在此基础上研究了手性源1与一系列硫醇类化合物及胺类化合物的反应,结果生成一类新颖不对称Michael加成/消除反应的立体专一性产物,它为新的手性源5-(1-(?)氧基)-4-硫醇基(或氨基(-3-氯-2(5-
Since the component of 2 (5-H) -furanone is widely present in natural product with physiological activity and is used as an intermediate for organic synthesis, in recent years, the organic chemistry has been widely used in the field of organic chemistry for the γ-substituent α, β- The research on the synthesis and structural properties of unsaturated butene lactones gives great interest and attention. We recently reported the synthesis and structure of the new chiral 5- (1- (?) Oxy) -3,4-dichloro-2 (5-H) -furanone. Based on this, the reaction of chiral source 1 with a series of thiols and amines has been studied. As a result, a novel stereospecific product of asymmetric Michael addition / elimination reaction has been generated, The 5 - (1- (?) Oxy) -4-thiol (or amino (-3-chloro-2-