【摘 要】
：
The gene delivery system is one of the three components of a gene medicine, which is the bottle neck of current gene therapy. Nonviral vectors offer advantages
【机 构】
：
Department of Chemistry
【基金项目】
：
国家重点基础研究发展计划(973计划);高等学校博士学科点专项科研项目;the Creative Fund of Wuhan University
论文部分内容阅读
The gene delivery system is one of the three components of a gene medicine, which is the bottle neck of current gene therapy. Nonviral vectors offer advantages over the viral system of safety, ease of manufacturing, etc. As important nonviral vectors, polymer gene delivery systems have gained increasing attention and have begun to show increasing promising. In this review, the fundamental and recent progress of polymer-based gene delivery vectors is reviewed.
其他文献
目的 了解2006年甘肃省地方性氟中毒病区水氟分布和降氟改水工程现状.方法 在18个病区县(市、区)对未改水病区村进行高氟水源筛查,对20世纪80年代以来各县(市、区)所建设的全
选择亚洲中部典型干涸尾闾湖——艾比湖干涸湖底及其下风向约200km的范围为研究区,并把研究区分为干涸湖底风蚀区和盐尘扩散堆积区两个子区.通过对两子区连续多年野外实地观
乙型肝炎病毒X基因(HBx)可通过与宿主细胞的多种蛋白相互作用,参与肝细胞癌(HCC)的发生和发展[1].但其详细机制尚未完全阐明.
Summary: To elucidate the intracellular signaling pathways for VLDL-induced VLDLR transcrip-tion, Western blot analysis was used to examine phosphorylated ERK1/
The kinetochore is structurally composed of four layers. We know that three microtubule-based motor proteins such as CENP-E, dynein, and MCAK are located at the
分别于7月15H～8月7H(夏季期)和9月5日～10月9H(秋季期),在山西芦芽山林线附近,应用树木径向变化记录仪(Dendrometer)分别测量了3株和4株华北落叶松树干的径向生长过程,并同步监
The intra- or inter-strain reconstituted blastocysts were produced by replacing the inner cell mass of Kunming mouse blastocysts with that of Kunming or C57BL/6
一般认为,中国古代史传叙述者属于"客观叙述者",这种观点过于笼统简单,本文意在辨析,在貌似客观的叙述背后,史家通过精心地控制叙事修辞,巧妙地传达叙述者的声音,因而其本质
The present study examined cardiac myocyte contractile and Ca2+ transient responses to insulin during simulated ischemia/reperfusion (I/R) and furtherinvestigat
Parotid secretory protein (PSP) secreted abundantly in saliva, whose function is related with the anti-bacterial effect. The PSP cDNA has been isolated from pig